Progesterone modulates SERCA2a expression and function in rabbit cardiomyocytes
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چکیده
منابع مشابه
AKIP1 Expression Modulates Mitochondrial Function in Rat Neonatal Cardiomyocytes
A kinase interacting protein 1 (AKIP1) is a molecular regulator of protein kinase A and nuclear factor kappa B signalling. Recent evidence suggests AKIP1 is increased in response to cardiac stress, modulates acute ischemic stress response, and is localized to mitochondria in cardiomyocytes. The mitochondrial function of AKIP1 is, however, still elusive. Here, we investigated the mitochondrial f...
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BACKGROUND Failing human myocardium is characterized by abnormal relaxation, a deficient sarcoplasmic reticulum (SR) Ca(2+) uptake, and a negative frequency response, which have all been related to a deficiency in the SR Ca(2+) ATPase (SERCA2a) pump. METHODS AND RESULTS To test the hypothesis that an increase in SERCA2a could improve contractile function in cardiomyocytes, we overexpressed SE...
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OBJECTIVE Downregulation of sarco-endoplasmic reticulum calcium ATPase 2a (SERCA2a) expression is a critical marker of pathological myocardial hypertrophy. The effects of calcium-dependent signaling and of contractile activity on the regulation of myocardial SERCA2a expression remain unclear. The present study dissociates effects of calcium-dependent signaling through calcineurin (CN) and calmo...
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OBJECTIVES Hypertrophy has been shown to be associated with arrhythmias which can be caused by abnormal remodeling of the Kv4-family of transient potassium channels. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) have recently been shown to exert pleiotropic protective effects in cardiovascular diseases, including anti-arrhythmias. It is hypothesized that remodeling of ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2014
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00127.2014